GLP-1 agonists, such as Semaglutide and Tirzepatide, can assist with weight loss through several mechanisms: Appetite suppression. Slowing gastric emptying, which can keep you full longer. Increased energy expenditure. GLP-1 agonists can enhance energy expenditure, meaning that the body burns more calories. These mechanisms make GLP-1 agonists an effective and safe way to lose weight and maintain the loss over time!